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. 2022 Sep 29;13:1020159. doi: 10.3389/fimmu.2022.1020159

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Copyright © 2022 Rudi, Martin Aispuro, Zurita, Gonzalez Lopez Ledesma, Bottero, Malito, Gabrielli, Gaillard, Stuible, Durocher, Gamarnik, Wigdorovitz and Hozbor

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SARS-CoV-2 trimeric spike protein variants were produced in stable CHO pool and purified using a proprietary 3-step chromatographic process and analyzed by reducing (R) and non-reducing (NR) SDS-PAGE (A) and analytical size exclusion chromatography (B) as described in materials and methods. All spikes elute from the SEC-UPLC column as a mixture containing various amounts of Hexamers, Trimers 1 and Trimers 2 species. SW: ancestral Wuhan spike; SD: Delta spike variant (B.1.617.2); SB: Beta spike variant (B.1.351).