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. 2022 Sep 29;13:1020159. doi: 10.3389/fimmu.2022.1020159

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Copyright © 2022 Rudi, Martin Aispuro, Zurita, Gonzalez Lopez Ledesma, Bottero, Malito, Gabrielli, Gaillard, Stuible, Durocher, Gamarnik, Wigdorovitz and Hozbor

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-spike IgG titers induced by a booster with SW-Vac 2µg formulation or commercial vaccine in mice. BALB/c mice (n = 8/group) were immunized on Days 0 and 14 with commercial Gam-COVID-Vac-rAd26/rAd5 vaccine plus a booster with SW-Vac formulation or Gam-COVID-Vac-rAd5 on Day 49 delivered intramuscularly (A). Serum collected on Day 14 after the last dose was analyzed by ELISA to determine the levels of W (B) or (C) S-specific IgG, IgG1 and IgG2a. Sera titers were obtained by plotting the OD 492 nm vs. log curve of the reciprocal of the dilution in the GraphPad Prism program. Titers are expressed as the inverse of the inflection point dilution of the curve. For statistical analysis, antibody titers were log-transformed and then analyzed by a one-way ANOVA with Bonferroni’s multiple comparisons test. For all treatments, the titers detected after the second dose were significantly different from those found after the first dose (p<0.0001).