Table 2.
Adjusted* logistic regression model of factors associated with pregnancy-associated melanoma (PAM) compared to non-PAM by primary tumor invasion status at diagnosis.
| All Invasive and in situ melanomas** | Invasive melanoma | |
|---|---|---|
| Characteristics | OR (95% CI) | OR (95% CI) |
|
| ||
| Age (each year) | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) |
| Race/ethnicity | ||
| Non-Hispanic white | Reference | Reference |
| Asian, Black and Native American | 0.81 (0.50, 1.30) | 0.54 (0.28, 1.05) |
| Hispanic | 1.29 (1.07, 1.56) | 1.39 (1.12, 1.73) |
| Other/unknown | 1.02 (0.83, 1.24) | 1.02 (0.78, 1.33) |
| Summary stage | ||
| Localized | Reference | Reference |
| Regional | 0.82 (0.43, 1.56) | 0.85 (0.44, 1.63) |
| Remote | 0.82 (0.37, 1.80) | 0.74 (0.33, 1.67) |
| Unknown | 1.87 (1.24, 2.81) | 1.75 (1.15, 2.65) |
| Tumor site | ||
| Lower limb and hip | Reference | Reference |
| Face | 1.07 (0.84, 1.36) | 1.09 (0.81, 1.46) |
| Scalp and neck | 0.83 (0.60, 1.13) | 0.79 (0.55, 1.13) |
| Skin of trunk | 0.95 (0.82, 1.09) | 0.94 (0.79, 1.11) |
| Upper limb and shoulder | 0.88 (0.76, 1.02) | 0.85 (0.71, 1.03) |
| Other | 0.58 (0.30, 1.11) | 0.58 (0.29, 1.18) |
| Histologic type | ||
| Superficial spreading melanoma | Reference | Reference |
| Nodular melanoma | 1 (0.68, 1.45) | 0.99 (0.68, 1.45) |
| Rare subtypes | 0.95 (0.65, 1.38) | 1.51 (0.87, 2.62) |
| Malignant melanoma, NOS | 1.04 (0.91, 1.18) | 1 (0.86, 1.16) |
| Tumor thickness (Breslow depth) | ||
| In situ | Reference | |
| 0.01–1.00 mm | 0.95 (0.82, 1.09) | Reference |
| 1.01–2.00 mm | 0.9 (0.70, 1.17) | 0.97 (0.77, 1.22) |
| 2.01–4.00 mm | 0.93 (0.65, 1.35) | 1 (0.70, 1.42) |
| > 4.00 mm | 1.03 (0.62, 1.72) | 1.11 (0.67, 1.83) |
| Unknown | 0.77 (0.57, 1.05) | 0.81 (0.60, 1.10) |
| Neighborhood SES | ||
| High | Reference | Reference |
| Low | 0.77 (0.68, 0.87) | 0.7 (0.61, 0.82) |
| Time to surgery | ||
| <30 days | Reference | Reference |
| 30–59 days | 0.88 (0.76, 1.03) | 0.85 (0.72, 1.02) |
| 60–89 days | 1 (0.75, 1.33) | 1.05 (0.76, 1.45) |
| ≥90 days | 0.77 (0.51, 1.14) | 0.96 (0.62, 1.49) |
| No surgery/unknown | 0.95 (0.71, 1.27) | 1.26 (0.87, 1.81) |
| Lymph nodes involvement | ||
| No lymph node involvement | Reference | Reference |
| Regional lymph nodes | 0.97 (0.51, 1.83) | 0.91 (0.48, 1.74) |
| Unknown | 0.99 (0.77, 1.26) | 1.01 (0.79, 1.29) |
| Lymph nodes examined | ||
| Yes | 1.12 (0.94, 1.34) | 1.14 (0.95, 1.37) |
| No | Reference | Reference |
| Insurance | ||
| Private | Reference | Reference |
| Public/none | 0.95 (0.76, 1.20) | 1.01 (0.78, 1.30) |
| Unknown | 0.83 (0.70, 0.97) | 0.71 (0.57, 0.89) |
Abbreviations: OR: Odds ratio; CI: confidence interval; mm: millimeter; SES: socioeconomic status; NOS: not otherwise specified
*
Adjusted for all the variables in the table
**
Total number of patients 13108