Figure 2. Commonly prescribed skeletal muscle relaxant + co-dispensed drug of the base-pair with candidate interacting precipitant associations with unintentional traumatic injury.

Panels A–D depict associations between 3DIs and unintentional traumatic injury when the object skeletal muscle relaxant of interest was cyclobenzaprine, tizanidine, baclofen, and methocarbamol, respectively. Semi-Bayes shrinkage prespecified a variance of 0.25, assuming that 95% of true rate ratios would fall within an unspecified 7-fold range of each other. The x-axis is the log base 2 of the semi-Bayes shrunk adjusted rate ratio (RR) comparing skeletal muscle relaxant + co-dispensed drug of base-pair + candidate interacting precipitant vs. skeletal muscle relaxant + co-dispensed drug of base-pair. The value of the X represents the magnitude of the RR, whereas the value of Y represents the level of statistical significance. Data points in the upper right quadrant represent statistically significant elevated rate ratios for the association between skeletal muscle relaxant + co-dispensed drug of base-pair + candidate interacting precipitant (vs. skeletal muscle relaxant + co-dispensed drug of base-pair) and injury (i.e., putative 3DI signals).