Table 2.
Summary data on rate ratios for unintentional traumatic injury, by skeletal muscle relaxant
| Skeletal Muscle Relaxant | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baclofen | Carisoprodol | Chlorzoxazone | Cyclobenzaprine | Dantrolene | Metaxalone | Methocarbamol | Orphenadrine | Tizanidine | |
| Unadjusted analyses | |||||||||
| Number of base-pair-candidate interacting precipitant triads examined | 11,942 | 4,777 | 223 | 18,725 | No models runa | 2,449 | 4,957 | 535 | 14,870 |
| Range of RRs after semi-Bayes shrinkage | 0.35 – 2.02 | 0.44 – 2.15 | 0.61 – 1.26 | 0.37 – 2.13 | 0.43 – 1.64 | 0.46 – 1.95 | 0.52 – 1.55 | 0.34 – 2.13 | |
| Number of statistically significantly elevated ratio of RRs | 2 | 1 | 0 | 12 | 0 | 2 | 0 | 8 | |
| Confounder-adjusted analyses b | |||||||||
| Number of base-pair-candidate interacting precipitant triads examined | 9,363 | 3,609 | 21 | 16,610 | No models runa | 975 | 3,223 | 17 | 12,330 |
| Range of RRs after semi-Bayes shrinkage | 0.38 – 2.06 | 0.41 – 2.05 | 0.55 – 0.84 | 0.33 – 2.20 | 0.44 – 1.69 | 0.43 – 2.14 | 0.79 – 1.68 | 0.33 – 2.28 | |
| Number of statistically significantly elevated ratio of RRs | 5 | 0 | 0 | 9 | 0 | 1 | 0 | 14 | |
| Final number of potential 3DI signals | 5 | 0 | 0 | 9 | n/a | 0 | 1 | 0 | 14 |
RR = rate ratio
a
No models were run because no base-pair-candidate interacting precipitant combinations had ≥5 exposed patients.
b
The number of triads decreased in the confounder-adjusted analyses compared to the unadjusted analyses because the adjusted models included time-varying covariates (i.e., average daily dose of SMR, follow-up month, and ever having a prior traumatic injury of interest). In some confounder-adjusted models, the estimates for one or more of the covariates were unstable; these models were considered invalid and not reported in confounder-adjusted analyses.