Table 2:

Cox proportional hazards regression model for unadjusted recurrence, liver recurrence, and extrahepatic recurrence-free survival in patients following complete resection of colorectal liver metastases with adjuvant hepatic artery infusion and systemic chemotherapy.

		Any Recurrence				Any Liver Recurrence				Any Extrahepatic Recurrence
		Univariable Analysis		Multivariable Analysis		Univariable Analysis		Multivariable Analysis		Univariable Analysis		Multivariable Analysis
Variable		HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age at resection		0.98 (0.97-1.00)	0.12			0.97 (0.95-0.99)	0.007	0.97 (0.95-0.99)	0.005	0.98 (0.96-1.00)	0.043	0.98 (0.96-1.00)	0.07
Primary T-Stage	T3-T4	2.29 (1.22-4.30)	0.010	2.01 (1.06-3.82)	0.032	1.97 (0.94-4.13)	0.07			2.22 (1.11-4.43)	0.024	2.06 (1.02-4.16)	0.044
	T0-T2	1.00		1.00		1.00				1.00		1.00
Clinical Risk Score	High (3-5)	1.66 (1.11-2.46)	0.013	1.45 (0.96-2.19)	0.08	1.73 (1.07-2.80)	0.026	1.39 (0.83-2.31)	0.21	1.79 (1.15-2.77)	0.010	1.70 (1.08-2.67)	0.021
	Low (0-2)	1.00		1.00		1.00		1.00		1.00		1.00
Preoperative Chemotherapy	Yes	1.51 (0.84-2.71)	0.16			1.48 (0.74-2.99)	0.20			1.23 (0.67-2.28)	0.50
	No	1.00				1.00				1.00
Extent of Hepatectomy	Major	0.80 (0.53-1.20)	0.28			0.58 (0.34-0.97)	0.038	0.51 (0.30-0.87)	0.014	0.93 (0.60-1.46)	0.76
	Minor	1.00				1.00		1.00		1.00
Liver Margin	R1	2.62 (1.31-5.24)	0.006	2.32 (1.13-4.74)	0.022	3.25 (1.47-7.19)	0.004	2.38 (1.03-5.49)	0.042	1.27 (0.51-3.13)	0.61
	R0	1.00		1.00		1.00		1.00		1.00
Ablation at Hepatectomy	Yes	1.80 (1.13-2.85)	0.013	1.44 (0.90-2.31)	0.13	2.28 (1.35-3.84)	0.002	2.04 (1.17-3.53)	0.012	1.39 (0.82-2.34)	0.22
	No	1.00		1.00		1.00		1.00		1.00
RAS-TP53	Co-Altered	2.05 (1.34-3.13)	<0.001	2.14 (1.38-3.31)	<0.001	1.95 (1.17-3.24)	0.010	1.79 (1.06-3.01)	0.029	2.57 (1.64-4.04)	<0.001	2.81 (1.78-4.44)	<0.001
	All others	1.00		1.00		1.00		1.00		1.00		1.00