Table 2.

Top 20 Tox21 assays that are predictive of DILI.

#	DILI Assay	Target	AUC
1	tox21-er-bla-antagonist-p1_ch1	ER-BLA antagonist viability	0.57
2	tox21-pxr-p1_ratio	PXR agonist	0.57
3	tox21-err-p1_agonist	ERR	0.56
4	tox21-mitotox-p1_rhodamine	Mitochondria toxicity	0.56
5	tox21-err-p1_ratio	ERR	0.56
6	tox21-are-bla-p1_ratio	ARE	0.55
7	tox21-casp3-cho-p1_viability	Caspase-3/7 cytotoxicity counter screen	0.55
8	tox21-mitotox-p1_ratio	Mitochondria toxicity	0.55
9	tox21-pr-bla-antagonist-p1_ch2	PR-BLA antagonist	0.55
10	tox21-are-bla-p1_ch2	ARE	0.55
11	tox21-p450-2c9-p1_ratio	CYP2C9	0.55
12	tox21-rxr-bla-agonist-p1_ch1	RXR-BLA control viability	0.55
13	tox21-pgc-err-p1_ratio	PGC-ERR	0.54
14	tox21-cre-antagonist-p1_ch2	CRE antagonist	0.54
15	tox21-ar-bla-antagonist-p1_ratio	AR-BLA antagonist	0.54
16	tox21-car-antagonist-p1_ratio	CAR antagonist	0.54
17	tox21-pparg-bla-agonist-p1_ratio	PPARγ agonist	0.54
18	tox21-ahr-p1_ratio	AhR	0.54
19	tox21-cre-agonist-p1_ch1	CRE control viability	0.54
20	tox21-cre-antagonist-p1_ratio	CRE antagonist	0.54