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. 2022 Sep 30;10:985298. doi: 10.3389/fcell.2022.985298

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Copyright © 2022 Wasserman, Huang, Lewis-Israeli, Dooley, Mitchell, Venkatesan and Aguirre.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome Analysis of Oxytocin-Treated Human Epicardial Cells. (A) Volcano plot showing differentially expressed genes between control and OXT-treated hEpiCs, as determined by RNA sequencing; Blue dots correspond to genes with a fold change ≥1.4 and a p-value ≤ 0.05. (B,C) Gene ontology analysis showing upregulated and downregulated biological processes (B) and molecular functions (C) after oxytocin exposure in hEpiCs. (D) Relative mRNA expression of ligands for the TGF-β pathway and activators of BMP signaling in control and OXT-treated hEpiCs; n = 3 per condition.