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. 2022 Oct 13;13:6056. doi: 10.1038/s41467-022-33827-3

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Fig. 1 — A Exit vector analysis to establish the 3D positions of substituents relative to each other. B Known aromatic ring isosteres for para-substituted aromatic rings with a representative example. C Known aromatic ring isosteres for meta-substituted aromatic rings. D [2]-Ladderane as isosteres for aromatic rings E [2]-Ladderane as rigidified cyclohexanes.