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. 2022 Sep 30;13:1002286. doi: 10.3389/fimmu.2022.1002286

Figure 1.

Figure 1

Commercial influenza vaccines used in this study. (A) Strain and lineage details for the influenza B HA proteins in the vaccines are provided for the 3 commercial vaccines studied: Flucelvax (Q), Fluad (T) and Fluzone (T). Influenza B HA of Victoria lineage is denoted as B-V, while influenza B HA of Yamagata-lineage is denoted as B-Y. Both the total HA concentration and the concentration of influenza B HA components are indicated. Fluad (T) and Fluzone (T) vaccines are trivalent (H1, H3, influenza B HA of B-V) or quadrivalent like Fluclevax (Q) (H1, H3, B-V, B-Y HAs). H1 and H3 strains are not shown for clarity. (B) Structural coordinate model for the trimeric ectodomain for hemagglutinin of influenza B (B/Florida/04/2006, B-Y). HA1 is read with HA2 in blue. (C) Conservation of amino acids between influenza B HA proteins in the vaccines and other Flu B HAs used in this study mapped onto a trimeric ectodomain in panel (B) Grey is more conserved while blue more variable. (D) Example of sequence alignment between a influenza B-V HA (B/Maryland/15/2016) and B-Y HA (B/Florida/04/2006). Colors represent the head (red) and stem (blue) regions of HA, residue differences are shown in black. N/A means not applicable.