Figure 3.

Assessing mice survival and weight loss between quadrivalent (Q) and trivalent (T) vaccines following influenza B (Yamagata-lineage) challenge. (A) Immunization and challenge schedule with prime and boost (day 0 and 21), intranasal challenge (day 42), and bleeds (day 0, 14, 35, and 56). (B) Weight-lost curves for 14 days following intranasal influenza B-Y challenge. (C) Corresponding survival curves. Vaccines were Flucelvax (Q) (green), Fluad (T) (blue) and Fluzone (T) (red) with saline control (black). Yamagata-lineage challenge virus was mouse-adapted B/Florida/04/2006. Challenge* denotes on the timeline when the challenge virus of Mouse Adapted B/Florida/04/2006 (Yamagata Lineage) was administered intranasally.