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Mangiferin enhanced Nrf2 antioxidant defense in a PPARϒ-dependent manner. Malondialdehyde (MDA) level (A), relative Nrf2 mRNA expression (B), relative Hmox1 mRNA expression (C), and total glutathione (GSH) content (D) were measured in the kidney of rats pretreated with MF or MF + BADGE then received MTX. Data is represented as (Mean ± SEM), N ≥ 4, * p ≤ 0.05 compared to control group, #p ≤ 0.05 compared to MTX group, $p ≤ 0.05 compared to MF group.
