Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 26;50(18):10449–10468. doi: 10.1093/nar/gkac807

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 2. — SMUG1 interacts with proteins involved in RNA metabolism and gene transcription. (A) Schematic representation of the workflow used for determining the SMUG1 interacting proteins in connection with analysis of TCGA expression data. (B) Proximity Ligation Assay (PLA) showing Flag-tagged SMUG1 (red) and SFPQ, MATR3, DNA Ligase I, NPM1 and RPLP0 (green) interaction in MCF7 cells. Scale bars, 1 μm. (C) Top 30 hubs of the SMUG1-PPI network, based on global metric, betweenness centrality. Color shades represent the significance of the hub, with red color as the most significant and yellow color as the least. (D) Functional enrichment analysis of SMUG1-PPI Network based on GO-Biological Processes (P < 0.05).