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RCU (relative codon usage) value for nonsynonymous substitutions and randomly mutated sequences toward the human. A: RCU value for each sample, plot by its collection date. B: Distribution of RCU value for different periods, the orange box shows the distribution of RCU for randomly mutated sequences. C: Distribution of RCU value for some lineages, the orange box shows the distribution of RCU for randomly mutated sequences. D: Distribution of collection date for lineages.
