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Schematic representation of the effects of SARS-CoV-2 on the renin-angiotensin system. SARS-CoV-2 reduces the expression of ACE2 and as a consequence leads to the accumulation of Ang II. Ang II promotes an inflammatory state through the release of cytokines. ACE2, angiotensin-converting enzyme 2; Ang II, angiotensin II.
