Table 3. The positive treatment for GNAO1 related MD.

Ref (PMID/DOI)	Positive treatment	GNAO1 variant	Sex	Inheritance	Age of onset	Seizures	MD
28357411	Tetrabenazine	p.Glu246Gly	Female	De novo	6 months	+	+
28357411	Tetrabenazine	p.Ser47Gly	Male	De novo	5 months	+	+
30838255	Tetrabenazine	p.Arg209His	Male	De novo	10 months		+
29758257	Tetrabenazine	p.Glu237Lys	Male	De novo	4 months		+
28668776	Tetrabenazine	p.Glu237Lys	Male	De novo	3 months		+
27068059	Tetrabenazine	p.Glu246Lys	Female	De novo	4 years		+
27068059	Tetrabenazine	p.Glu246Lys	Female	De novo	6 months		+
27068059	Tetrabenazine	p.Glu246Lys	Male	De novo	14 years		+
28668776	Tetrabenazine	p.Glu246Lys	Female	De novo	3 months		+
DOI: 10.1055/s-0036-1597627	Levetiracetam	p.Gly45Arg	Male	De novo	unknown	+	+
29758257	Levetiracetam	p.Glu237Lys	Male	De novo	4 months		+
25966631/27916449	Topiramate	p.Arg209Cys	Female	De novo	11 months		+
30838255	Trihexyphenidyl	p.Arg209His	Male	De novo	10 months		+
33358199	Gabapentin	p.Arg209Cys	Female	De novo	2 years		+
Our study	oxcarbazepine	p.Glu237Lys	Male	De novo	4 years		+
32044685	DBS + levodopa	p.Ser207Phe	Female	De novo	16 years		+
31076915	DBS	p.Glu246Lys	Female	Unknown	13 months		+
31076915	DBS	p.Glu246Lys	Female	Unknown	4 years	+	+
30103967	DBS	c.723+1G>T	Female	De novo	3 years		+
30103967	DBS	p.Arg209Cys	Female	De novo	0 month	+	+
30103967	DBS	p.Glu237Lys	Male	De novo	0 month		+
29661126	DBS	p.Arg209Leu	Male	De novo	18 months
28357411	DBS	p.Glu246Gly	Female	De novo	6 months	+	+
28668776	DBS	p.Glu237Lys	Male	De novo	3 months		+
28668776	DBS	p.Glu246Lys	Female	De novo	3 months		+
26060304	DBS	p.Arg209His	Male	De novo	18 months		+
26060304	DBS	p.Arg209His	Male	De novo	2 years		+
28668776	DBS	p.Arg209Cys	Female	De novo	6 months	+	+
29661126	DBS	p.Arg209Leu	Male	De novo	2 years		+
27278281	DBS	p.Gln233Phe	Female	De novo	13 months		+

MD, movement disorder; DBS, deep brain stimulation. ‘+’, positive.