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. 2022 Sep;11(9):1562–1569. doi: 10.21037/tp-22-475

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2022 Translational Pediatrics. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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EE1 and EE2 groups alleviated NMS-induced depression-like behaviors. (A) Schematic of SPT. (B) Total liquid intake and (C) sucrose preference rate in SPT. (D) Schematic of FST. (E) Time of immobility in FST. All data were expressed as mean ± SD. **, P<0.01 vs. Control group; ^#, P<0.05 vs. NMS group. NMS, neonatal maternal separation; EE, enriched environment; EE1 group, prepubertal EE group; EE2 group, pubertal EE group; EE3 group, adult EE group; SPT, sucrose preference test; FST, forced swimming test; SD, standard deviation.