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. 2022 Oct 6;10(28):9970–9984. doi: 10.12998/wjcc.v10.i28.9970

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Severe acute respiratory syndrome coronavirus 2 entry into angiotensin converting enzyme 2 is facilitated by transmembrane protease serine 2 induced activation of the S protein via its serine protease activity. Inhibition of transmembrane protease serine 2 (TMPRSS2) may furnish an alternative strategy to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking viral entry into host cells. ACE2: Angiotensin converting enzyme 2. Citation: Triposkiadis F, Xanthopoulos A, Giamouzis G, Boudoulas KD, Starling RC, Skoularigis J, Boudoulas H, Iliodromitis E. ACE2, the Counter-Regulatory Renin-Angiotensin System Axis and COVID-19 Severity. J Clin Med 2021; 10: 3885. Copyright ©The Author(s) 2021. Published by MDPI.