Table 2.
Multivariate Cox proportional hazards analysis: EPclin score.
| Variable | Reference | Level | HR (95% CI) | P |
|---|---|---|---|---|
| EPclin score (continuous) | — | — | 2.91 (1.70–4.97) | 8.3 x 10–5 |
| Age at diagnosis (continuous) | — | — | 0.96 (0.90–1.02) | 0.18 |
| Tumor grade (categorical) | I | II | 8.98 x 107 (0–∞) | 5.8 x 10–2 |
| III | 1.01 x 108 (0–∞) | |||
| Missing | 0.72 (0–∞) | |||
| Ki-67 (categorical) | ≤5% | 6%–29% | 2.51 (0.57–10.97) | 0.41 |
| ≥30% | 1.61 (0.33–7.97) | |||
| Missing | 3.88 (0.33–46.14) | |||
| ER expression (%; continuous) | — | — | 0.99 (0.97–1.02) | 0.59 |
| PgR expression (%; continuous) | — | — | 1.00 (0.99–1.01) | 0.69 |
Note: Model is stratified by site; analysis includes 34/381 (Events/N). PgR expression was missing for 4 patients, one of whom had a distant recurrence within 10 years.
Abbreviations: ER, estrogen receptor; PgR, progesterone receptor.