Figure 2.

Locally delivered MSCs improved structure and function of regenerating tissue in bone defects; this improvement was not affected by fNP labeling

(A) Micro-CT of the defect on PSD 10.

(B) Strain fields on tibia surface with defects under 3–12 N of axial loading, measured by DIC; red dotted line, defect region.

(C–G) Structural properties and bone mineral density (BMD) of defect regions on PSD 10; n = 6 mice; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001.

(H) Axial strain on defect region under 3–12 N of loading; n = 6 mice. ^∗∗p < 0.01, ^∗∗∗∗p < 0.0001.

(I) Movat’s pentachrome staining of a tibia with MTD (left) and zoom-in defect regions (right). Scale bars, 80 μm; c, cortical bone; d, defect area.

(J) Bone area from Movat’s pentachrome staining; n = 6 mice; ^∗∗∗p < 0.001.