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. 2022 Oct 13;12:17152. doi: 10.1038/s41598-022-22140-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of genes involved in oxytosis/ferroptosis, and parthanatos is significantly increased in ischemic RGCs. (A) Prussian blue stain indicates a high content of iron in neurons of ischemic and normotensive retinas. Prussian blue is specific for ferric iron (Fe3+). (B, C) Immunohistochemistry (IHC) analysis reveals that Steap3, the key enzyme generating ferrous (Fe2+) iron from ferric (Fe3+) iron, is highly expressed in the ischemic retina. Rbpms and Tubb3 are RGC markers. (D) IR results in high expression of Parp1 in RGCs.