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. 2022 Oct 13;12:17189. doi: 10.1038/s41598-022-22179-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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AD dysregulated genes reversed by exercise (human dataset). (A) Genes with the highest levels of protein–protein interaction (determined via STRING¹⁵) from the 409 AD genes reversed by exercise (top treatment; human high versus low activity) are plotted in Cytoscape¹⁰⁹. Increased size of font for gene symbol reflects higher number of connections between genes. CDC42, STAT3, NOTCH1, SNCA, YWHAZ, and MAPK8 were among the genes with the most connections. Interactions are highlighted by lines. (B) Blood vessel development genes were enriched within the AD genes reversed by exercise and are plotted in STRING¹⁵. Connections between proteins are shown by lines and color of line indicates type of evidence: light blue (known interactions from curated databases); pink (known interactions that are experimentally determined); green (predicted interactions from gene neighborhood); red (predicted interactions from gene fusions); blue (predicted interactions from gene co-occurrence); light green (text mining); black (co-expression); and gray (protein homology). AD upregulated genes downregulated by exercise are shown in red and AD downregulated genes upregulated by exercise are shown in blue for both (A,B).