Table 4.
Univariate and multivariate analyses showing the association of clinicopathological characteristics and LCR with the occurrence of postoperative complications.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Complication | No complication | P value | OR | 95%CI | P value | |
| Age (years) | ||||||
| ≤ 69 | 28 | 95 | ||||
| > 70 | 24 | 55 | ||||
| Sex | ||||||
| Male | 38 | 83 | 2.21 | 1.07–4.57 | 0.031* | |
| Female | 14 | 67 | 0.033* | |||
| BMI (kg/m2) | ||||||
| ≤ 25 | 7 | 36 | ||||
| > 25 | 45 | 114 | 0.110 | |||
| Location | ||||||
| High | 17 | 81 | ||||
| Low | 35 | 69 | 0.008* | 2.44 | 1.23–4.88 | 0.011* |
| Operative approach | ||||||
| Open | 4 | 18 | ||||
| Laparoscopy | 48 | 132 | 0.452 | |||
| CEA (ng/mL) | ||||||
| ≤ 5 | 33 | 99 | ||||
| > 5 | 19 | 51 | 0.740 | |||
| Preoperative treatment | ||||||
| None | 38 | 129 | ||||
| nCRT | 12 | 17 | ||||
| NAC | 2 | 4 | 0.097 | |||
| Operation time (minutes) | ||||||
| ≤ 300 | 22 | 79 | ||||
| > 300 | 30 | 71 | 0.198 | |||
| Blood loss (mL) | ||||||
| ≤ 100 | 33 | 114 | ||||
| > 100 | 16 | 34 | 0.177 | |||
| pT classification | ||||||
| pT0–2 | 49 | 145 | ||||
| pT3–4 | 3 | 5 | 0.872 | |||
| pN classification | ||||||
| Positive | 16 | 40 | ||||
| Negative | 36 | 110 | 0.569 | |||
| LCR | ||||||
| > 12,600 | 34 | 130 | ||||
| ≤ 12,600 | 18 | 20 | < 0.001* | 3.51 | 1.63–7.58 | 0.001* |
CI confidence interval, BMI body mass index, CEA carcinoembryonic antigen, nCRT neoadjuvant chemoradiotherapy, NAC neoadjuvant chemotherapy, pT pathological stage based on the tumor size and spread of cancer to nearby tissue, pN pathological stage based on spread of cancer to nearby lymph nodes, LCR lymphocyte count/C-reactive protein ratio. *P < 0.05