Table 5.
Univariate and multivariate analyses showing impact of clinicopathological characteristics and LCR on OS and RFS.
| Variables | OS | RFS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||||
| n | 5-year OS (%) | P value | HR | 95%CI | P value | 5-year RFS (%) | P value | HR | 95%CI | P value | |
| Age (years) | |||||||||||
| ≤ 69 | 123 | 92.7 | 76.6 | ||||||||
| > 70 | 79 | 67.6 | < 0.001* | 2.94 | 1.49–5.77 | 0.002* | 61.1 | 0.008* | 2.04 | 1.20–3.47 | 0.008* |
| Sex | |||||||||||
| Male | 121 | 84.6 | 66.9 | ||||||||
| Female | 81 | 80.5 | 0.909 | 76.8 | 0.153 | ||||||
| Location | |||||||||||
| High | 98 | 86.6 | 73.1 | ||||||||
| Low | 104 | 79.6 | 0.156 | 68.2 | 0.586 | ||||||
| BMI (kg/m2) | |||||||||||
| ≤ 25 | 159 | 82.5 | 70.2 | ||||||||
| > 25 | 43 | 84.5 | 0.53 | 72.0 | 0.549 | ||||||
| Operative approach | |||||||||||
| Open | 22 | 65.5 | 71.1 | ||||||||
| Laparoscopy | 180 | 85.2 | 0.083 | 66.9 | 0.495 | ||||||
| CEA (ng/mL) | |||||||||||
| ≤ 5 | 132 | 90.8 | 79.0 | ||||||||
| > 5 | 70 | 67.8 | < 0.001* | 1.80 | 0.88–3.69 | 0.106 | 54.8 | < 0.001* | 1.33 | 0.77–2.30 | 0.309 |
| pT classification | |||||||||||
| pT0–2 | 101 | 90.3 | 86.0 | ||||||||
| pT3–4 | 101 | 76.1 | 0.003* | 2.22 | 0.98–5.01 | 0.056 | 55.9 | < 0.001* | 3.00 | 1.54–5.85 | 0.001* |
| pN classification | |||||||||||
| Negative | 146 | 87.8 | 79.0 | ||||||||
| Positive | 56 | 70.7 | 0.007* | 1.66 | 0.84–3.28 | 0.132 | 49.6 | < 0.001* | 2.32 | 1.33–4.03 | 0.003* |
| Preoperative treatment | |||||||||||
| None | 167 | 84.5 | 72.4 | ||||||||
| nCRT | 29 | 78.6 | 66.7 | ||||||||
| NAC | 6 | 66.7 | 0.111 | 61.4 | 0.525 | ||||||
| Operation time (minutes) | |||||||||||
| ≤ 300 | 101 | 83.7 | 74.6 | ||||||||
| > 300 | 101 | 82.2 | 0.892 | 66.7 | 0.349 | ||||||
| Blood loss (mL) | |||||||||||
| ≤ 100 | 147 | 89.5 | 76.2 | ||||||||
| > 100 | 50 | 61.1 | < 0.001* | 2.74 | 1.38–5.43 | 0.004* | 52.0 | 0.004* | 2.38 | 1.36–4.18 | 0.003* |
| Histology | |||||||||||
| Well/mod, papillary | 188 | 84.0 | 71.3 | ||||||||
| Poor, mucinous | 9 | 63.5 | 0.226 | 63.5 | 0.713 | ||||||
| LCR | |||||||||||
| > 12,600 | 164 | 84.7 | 73.0 | ||||||||
| ≤ 12,600 | 38 | 75.2 | 0.039* | 2.07 | 1.03–4.15 | 0.041* | 60.0 | 0.025 | 2.21 | 1.22–4.01 | 0.009* |
CI confidence interval, HR hazard ratio, OS overall survival, RFS recurrence-free survival, BMI body mass index, CEA carcinoembryonic antigen, pT pathological stage based on the tumor size and spread of cancer to nearby tissue, pN pathological stage based on spread of cancer to nearby lymph nodes, well/mod well-differentiated/moderately-differentiated, poor poorly-differentiated, LCR lymphocyte count/C-reactive protein ratio. *P < 0.05