Fig. 6.

Central projections of auditory and vestibular sensory afferents depend on proper development of the dorsal hindbrain. In Lmx1a/b DKO mice vestibular neurons (VN) project dorsally in the hindbrain as in control mice, whereas auditory projections fail to develop (A, B). However, in Lmx1a/b DKO mice, vestibular projections cross the midline through the roof plate, which is continuous across the midline due to the absence of the choroid plexus (B). Choroid plexus development depends on the expression of Atoh1, Gdf7 and Wnt1/3a which is lost in the absence of Lmx1a/b expression (A, B). AC, HC, PC, anterior, horizontal, posterior cristae; CN, cochlear nuclei; S, saccule; SGN, spiral ganglion neurons; ST, solitary tact; U, utricle; VestN, vestibular nuclei; VN, vestibular ganglion neurons. Reprinted with permission from (Chizhikov et al., 2021, Elliott et al., 2021, Glover et al., 2018, Lee et al., 2000).