Scheme 2.

Schematic illustration of the co‐incubation system to simulate tumor immune microenvironment. A) Schemes showing the isolation of BMDC, BMDM, T lymphocytes, and the polarity of M1 and M2. B) The tumor cells were pre‐treated with TBD‐3C upon light illumination to obtain pyroptotic cells before co‐culture. C) Pyroptotic cells were co‐cultured with BMDM. D) Pyroptotic cells were co‐cultured with BMDC. E) The polarized BMDM cells were collected to co‐culture with fresh tumor cells again. F) Pyroptotic cells were co‐cultured with M2. G) Pyroptotic cells were co‐cultured with T lymphocytes. H) Pyroptotic cells were co‐cultured with T lymphocytes, BMDM, and BMDC.