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. 2022 Sep 30;12:960858. doi: 10.3389/fonc.2022.960858

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Copyright © 2022 Zhu, Wang, Zhang, Gong, Zhang, Yang, Qu, Wu, Ma, Wang and Qian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Huaier inhibited pancreatic cancer tumour growth in vivo by inducing ferroptosis. (A) Macroscopic images of pancreatic cancer tumours in the control, Huaier and Huaier plus ferrostain-1 (Fer-1) groups and statistical graph of their tumour weights. (B) H&E staining showed the micropathological morphology of pancreatic cancer tumours in the control, Huaier and Huaier plus Fer-1 groups. (C) Prussian blue staining and IHC staining of COX2, SLC7A11 and GPX4 in pancreatic cancer tumours in the control, Huaier and Huaier plus Fer-1 groups. *P < 0.05, scale bar = 100 μm.