Table 3.
Malignant transformation of potentially malignant oral disorders reported in the systematic reviews and meta-analyses published in the special issue organized by the World Health Organization Collaborating Centre for Oral Cancer.
| Potentially Malignant Oral Disorders | Sample Size (Primary-Level Studies) | Number of Patients | Malignant transformation * | WHO Collaborating Centre for Oral Cancer Special Issue |
|---|---|---|---|---|
| Oral leukoplakia | n = 24 ** | 16,192 | PP = 9.8% (95% CI: 7.9–11.7) |
Aguirre-Urízar et al., 2021 |
| Oral Lichen Planus | n = 10 *** | 3206 | PP = 2.28% (95% CI = 1.49–3.20) |
González-Moles et al., 2020 |
| Oral Lichenoid Lesions | n = 3 | 197 | PP = 2.11% (95% CI = 0.01–6.33) |
González-Moles et al., 2020 |
| Proliferative Verrucous Leukoplakia | n = 17 | 474 | PP = 43.87% (95% CI = 31.93–56.13) |
Ramos-García et al., 2021 |
| Oral Submucous Fibrosis | n = 9 | 6337 | PP = 4.2% (95% CI: 2.7%–5.6%) |
Kujan et al., 2020 |
* This table only integrates those OPDMs for which there is scientific evidence of their malignant transformation poroportions studied through meta-analyses and published in the WHO Collaborating Centre for Oral Cancer special issue. ** Published in the last 5 years. *** Based on 10 highest quality studies selected out of 89 publications. Abbreviations: WHO, World Health Organization; PP, pooled proportions; CI, confidence intervals.