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BR102 reversed PD-L1/PD-1 mediated immunosuppression and enhanced T cell activation. BR102 blocked PD-1/PD-L1 interaction (A) and CD80/ PD-L1 interaction (B) in competition ELISA assays. (C) The blockade ability of HS636 on PD-1/PD-L1 signaling was determined by the NFAT reporter gene assay. (D) DCs and allogeneic PBMC from 2 donors were co-cultured in the presence of indicated concentrations of BR102 or HS636 for 3 days. IL-2 secretion was analyzed by ELISA.
