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. 2022 Oct 10;14(19):4964. doi: 10.3390/cancers14194964

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Treatment with BR102 is well tolerated in non-human primates. BR102 was administered to cynomolgus monkeys at 15, 50, and 100 mg/kg (five males and five females for each group) once weekly for a total of 4 weeks. Peripheral blood was collected for hematology during the pre-dose phase; on Days 2 and 16 of the dosing phases; and on Days 30 and 71 of the recovery periods. Hematology parameters, including RBC (A), HGB (B), HCT (C), and reticulocytes (D) were measured. Values are presented as mean ± SD.