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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Immunology. 2022 Jul 30;167(3):354–367. doi: 10.1111/imm.13541

Figure 4 – Characterization of disease phenotype in NZM2410 lupus-prone CD11c-Cre/ERαflox/flox mice.

Figure 4 –

Data was collected from Cohort 1 (male and female, as above) plus a second all-female cohort sacrificed at 25 weeks. (A) Body and spleen weight for CrePos and CreNeg female mice. (B) serum anti-dsDNA measured by ELISA for all mice at the 25 week time point. Positive controls from diseased MRL/lpr mice (open grey circles) and negative controls from C57BL/6J mice (open grey square) are included. Panel C demonstrates albuminuria in mice ages 25–35 weeks old (highest recorded) as measured by 24hr urine collection on metabolic cages.