Table 2.
Baseline and follow-up MRI indices in WMLs and NAWM in SVD.
| NAWM | p-Value | WMLs | p-Value | |||
|---|---|---|---|---|---|---|
| Baseline | Follow-up | Baseline | Follow-up | |||
| QS (ppb) | −0.876 ± 0.534 | −0.748 ± 0.574 | 0.029 | 7.048 ± 4.411 | 8.017 ± 4.744 | 0.086 |
| FW | 0.341 ± 0.020 | 0.345 ± 0.019 | 0.167 | 0.371 ± 0.027 | 0.376 ± 0.033 | 0.270 |
| FA | 0.331 ± 0.016 | 0.329 ± 0.017 | 0.253 | 0.367 ± 0.079 | 0.383 ± 0.072 | 0.146 |
| FAt | 0.407 ± 0.024 | 0.403 ± 0.025 | 0.055 | 0.509 ± 0.111 | 0.525 ± 0.110 | 0.313 |
| MD (× 10−3mm2s−1) | 0.901 ± 0.052 | 0.906 ± 0.052 | 0.357 | 1.024 ± 0.092 | 1.026 ± 0.114 | 0.900 |
| MDt (× 10−3mm2s−1) | 0.653 ± 0.059 | 0.663 ± 0.058 | 0.109 | 0.700 ± 0.094 | 0.707 ± 0.111 | 0.557 |
| Volume (cc) | 598.146 ± 54.194 | 598.474 ± 59.233 | 0.918 | 5.268 ± 7.224 | 5.193 ± 7.022 | 0.599 |
WMLs, white matter lesions; NAWM, normal-appearing white matter; SVD, small vessel disease; QS, quantitative susceptibility; FW, free water; FA, fractional anisotropy; Fat, FW-corrected FA; MD, mean diffusivity; MDt, FW-corrected MD.
p-value < 0.05 was considered statistically significant (highlighted in bold).