Table 3. Relative Rates of Invasive Breast Cancer and DCIS, per 5-Year Treatment Era, Without and With Adjustment for Treatment Variables^a.

Adjusted treatment variables	Invasive		DCIS
	RR (95% CI)	P value	RR (95% CI)	P value
All survivors
Not adjusted for treatment	0.82 (0.74-0.90)	<.001	1.10 (0.94-1.28)	.24
Adjusted chest RT	0.89 (0.81-0.99)	.03	1.22 (1.05-1.41)	.009
Adjusted for chest RT, anthracycline dose, and pelvic RTb	0.86 (0.77-0.96)	.006	1.13 (0.97-1.32)	.11
HL survivors
Not adjusted for treatment	0.90 (0.80-1.01)	.07	1.14 (0.97-1.35)	.12
Adjusted chest RT	0.98 (0.86-1.11)	.73	1.20 (0.99-1.45)	.06
Adjusted for chest RT, anthracycline dose, and pelvic RTb	0.94 (0.81-1.10)	.45	1.03 (0.83-1.28)	.79
Survivors other than HL
Not adjusted for treatment	0.82 (0.70-0.97)	.02	1.36 (1.04-1.78)	.03
Adjusted chest RT	0.83 (0.70-0.97)	.02	1.40 (1.06-1.84)	.02
Adjusted for chest RT, anthracycline dose, and pelvic RTb	0.79 (0.67-0.94)	.007	1.41 (1.08-1.85)	.01

Abbreviations: DCIS, ductal carcinoma in situ; HL, Hodgkin lymphoma; RR, relative rate; RT, radiation therapy.

^a All models adjusted for attained age as cubic splines and age at diagnosis. The addition of cyclophosphamide equivalent dose to the model does not change the slope of the 5-year treatment era and hence is not shown.

^b The mode included the interaction of chest RT by anthracycline dose.