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. 2022 Oct 13;17(10):e0275564. doi: 10.1371/journal.pone.0275564

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© 2022 Bath et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) IgM and (B) IgG secreting cells were measured in spleen, bone marrow, and lymph node tissues using ELISPOT. Each graph shows number of spots per 62,500 lymphocytes. Spots represent antibody secreting cells. Data analyzed using ANOVA. BLyS^-/- significantly depleted IgM and IgG secreting cells in all tissues compared to both WT and APRIL^-/-. This effect was not seen in APRIL^-/- animals.