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. 2022 Sep 25;11(19):2986. doi: 10.3390/cells11192986

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of non-viable Lactobacillus gasseri strains on the lung tissue injury induced by the activation of Toll-like receptor 3 (TLR3). Infant mice were nasally primed with non-viable L. gasseri TMT36 (HK36), TMT39 (HK39), or TMT40 (HK40) during two consecutive days and challenged with three once-daily doses of poly(I:C). Non-lactobacilli treated mice challenged with poly(I:C) were used as controls. Lung wet: dry ratio, broncho-alveolar lavages (BAL) concentrations of albumin and proteins, and lactate dehydrogenase (LDH) activity were evaluated 2 days after the last poly(I:C) administration. The results represent data from three independent experiments. Significant differences were observed when compared to the control group * (p < 0.05), ** (p < 0.01).