Table 2.
The relationship between antiplatelet agent use and 5-year rate of ischemic stroke recurrence among patients with first-time hemorrhage stroke (n = 7589).
| Variables | Number | Number of IS event | Person-years | Incidence rate per 100 person-years | Crude HR (95% CI) | Adjusted HR (95% CI) |
|---|---|---|---|---|---|---|
| Age | ||||||
| 20–44 | 970 | 22 | 4259.6 | 0.52 | Ref | Ref |
| 45–59 | 2704 | 157 | 11,294.0 | 1.39 | 2.68 (1.71–4.18) | 2.17 (1.38–3.41) |
| ≥ 60 | 3915 | 286 | 13,318.7 | 2.15 | 4.05 (2.62–6.24) | 2.99 (1.91–4.68) |
| Sex | ||||||
| Female | 2978 | 171 | 11,381.1 | 1.50 | Ref | Ref |
| Male | 4611 | 294 | 17,491.3 | 1.68 | 1.12 (0.93–1.35) | 1.23 (1.02–1.49) |
| Length of stay, days | ||||||
| < 9 | 1831 | 140 | 7485.4 | 1.87 | Ref | Ref |
| ≥ 9 | 5758 | 325 | 21,386.9 | 1.52 | 0.81 (0.66–0.99) | 0.90 (0.73–1.11) |
| ICU | ||||||
| No | 6036 | 399 | 23,614.7 | 1.69 | Ref | Ref |
| Yes | 1553 | 66 | 5257.6 | 1.26 | 0.74 (0.57–0.96) | 0.86 (0.76–0.97) |
| CCI | ||||||
| < 5 | 5029 | 295 | 20,121.6 | 1.47 | Ref | Ref |
| ≥ 5 | 2560 | 170 | 8750.7 | 1.94 | 1.29 (1.07–1.56) | 0.87 (0.70–1.08) |
| Antiplatelet agents | ||||||
| No | 5529 | 306 | 19,990.5 | 1.53 | Ref | Ref |
| Yes | 2060 | 159 | 8881.8 | 1.79 | 1.18 (0.97–1.43) | 0.90 (0.74–1.09) |
| Diabetes mellitus | ||||||
| No | 5251 | 286 | 20,459.9 | 1.40 | Ref | Ref |
| Yes | 2338 | 179 | 8412.4 | 2.13 | 1.50 (1.25–1.81) | 1.28 (1.04–1.57) |
| Hypertension | ||||||
| No | 842 | 14 | 3237.6 | 0.43 | Ref | Ref |
| Yes | 6747 | 451 | 25,634.7 | 1.76 | 4.02 (2.36–6.84) | 2.68 (1.55–4.63) |
| Hyperlipidemia | ||||||
| No | 5250 | 287 | 19,453.8 | 1.48 | Ref | Ref |
| Yes | 2339 | 178 | 9418.5 | 1.89 | 1.29 (1.07–1.55) | 1.11 (0.92–1.35) |
| AF | ||||||
| No | 7269 | 425 | 27,910.2 | 1.52 | Ref | Ref |
| Yes | 320 | 40 | 962.1 | 4.16 | 2.64 (1.91–3.65) | 1.97 (1.40–2.76) |
| CVD | ||||||
| No | 5587 | 291 | 21,742.8 | 1.34 | Ref | Ref |
| Yes | 2002 | 174 | 7129.5 | 2.44 | 1.80 (1.49–2.17) | 1.42 (1.15–1.74) |
| CHF | ||||||
| No | 4164 | 220 | 16,216.6 | 1.36 | Ref | Ref |
| Yes | 3425 | 245 | 12,655.8 | 1.94 | 1.41 (1.18–1.69) | 0.98 (0.81–1.20) |
| The history of IS | ||||||
| No | 7272 | 429 | 27,966.0 | 1.53 | Ref | Ref |
| Yes | 317 | 36 | 906.3 | 3.97 | 2.51 (1.79–3.53) | 1.69 (1.18–2.40) |
ICU, intensive care unit; CI, confidence interval; AF, atrial fibrillation; CHF, congestive heart failure; IS, ischemic stroke; HR, hazard ratio; CVD, cardiovascular disease.