Table 1.
Baseline data of 33 patients who were eligible for analyses of primary and secondary endpoints randomized to Ramipril or Ramipril + Dapagliflozin treatment arms.
| Ramipril only (n = 16) | Ramipril + Dapagliflozin (n = 17) | |
|---|---|---|
| Gender | Males: 11 (68.8%) | Males: 13 (76.5%) |
| Mean Age (years) | 60 (8.3) | 55.5 (9.7) |
| Mean duration of diabetes (years) | 14.2 (4.9) | 14.4 (3.9) |
| Body mass index (kg/m2) | 30.9 (4.1) | 32.9 (3.9) |
| Systolic blood pressure (mmHg) | 138 (21) | 139 (14) |
| Diastolic blood pressure (mmHg) | 79 (7) | 83 (9) |
| Aortic pulse wave velocity (m/s) | 9.88 (2.12) | 9.06 (1.91) |
| Central systolic blood pressure (mmHg) | 128 (17) | 120 (15) |
| Central diastolic blood pressure (mmHg) | 81(8) | 82 (9) |
| Central pulse pressure (mmHg) | 47 (13) | 38 (11) |
| Augmentation index at HR75 % | 19.51 (8.25) | 18.85 (6.11) |
| Albumin excretion rate (μg/min)* | 108.0 (72.4, 316.0) | 35.3 (27.1, 71.5) |
| eGFR (ml/min/1.73 m2) | 94.6 (23.5) | 98.2 (20.9) |
| HbA1c (%) | 9.2 (1.2) | 8.9 (1.1) |
| Fasting glucose (mmol/l) | 9.7 (4.0) | 10.8 (3.3) |
| Serum sodium (mmol/l) | 138.5 (3.4) | 137.8 (2.7) |
| Serum potassium (mmol/l) | 4.4(0.4) | 4.4 (0.5) |
| Serum creatinine (umol/l) | 79.7 (19.5) | 74.1(15.4) |
| Total cholesterol (mmol/l) | 4.2 (1.0) | 4.1 (1.3) |
| LDL cholesterol (mmol/l) | 2.3 (0.9) | 1.9 (1.1) |
| HDL (mmol/l) | 1.3 (0.4) | 1.3 (0.3) |
| Triglycerides (mmol/l) | 1.8 (1.7) | 2.1 (1.3) |
| Hemoglobin (g/L) | 128.1 (13.9) | 140.9 (15.8) |
| Haematocrit (vol%) | 38.7 (3.9) | 41.1 (5.1) |
| ACE-2 (ng/L) | 29.01 (45.42) | 25.83 (32.41) |
| Plasma Aldosterone (ng/L) | 99.03 (45.36) | 84.75 (43.06) |
| Angiotensin 1.7 (ng/L) | 54.29 (22.97) | 86.26 (31.74) |
| Angiotensin 1.9 (ng/L) | 166.56 (36.33) | 207.55 (91.29) |
| FGF-23 (ng/L) | 12.95 (11.27) | 11.67 (13.17) |
| s-Klotho (ng/L) | 851 (433.02) | 795.45 (437.94) |
| Active renin (ng/L) | 27.13 (38.46) | 48.10 (42.64) |
Data mean (standard deviation) or median *interquartile range shown.
eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; FGF-23, Fibroblast growth factor 23; HDL, high density lipoprotein; LDL, low density lipoprotein; ACE, angiotensin converting enzyme.