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. 2021 Apr 18;1(2):100024. doi: 10.1016/j.xops.2021.100024

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© 2021 by the American Academy of Ophthalmology.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Photomicrographs showing PAX8 expression in retrocorneal and keratoprosthesis membranes. A–E, Epithelial downgrowth and capsular fibrosis. A, Variably thick basement membrane material, compatible with lens capsule (arrow) and adjacent capsular fibrosis (double arrowheads). Also note the overlying cornea with uniformly thick Descemet membrane (single arrowhead). B, Higher magnification highlighting surface epithelial membrane on the posterior corneal surface and focally on the surface of lens capsule (arrowheads). Capsular fibrosis with black iris melanin pigment (arrow) is present beneath the thick anterior lens capsule. C, cytokeratin (CK5/6) results are strongly positive in the corneal surface epithelium and in the epithelial membrane (arrowheads), compatible with epithelial downgrowth. D, PAX8 results are positive focally in the nuclei of epithelial downgrowth (arrowheads and upper inset). The capsular nuclei of fibroblast-like cells in capsular fibrosis (arrow) and lower inset (arrow) show negative results for PAX8. E, Vimentin shows positive results in the capsular fibrosis (arrow) and in the corneal stromal fibroblasts (single arrowhead) and negative results in the epithelial downgrowth (double arrowheads). F–H, Lens epithelial fibrous metaplasia in keratoprosthesis membrane. F, Spindle cell proliferation, associated with periodic acid–Schiff (PAS)-positive basement membrane material surrounding a segment of distorted and degenerated iris. G, Higher magnification highlighting a few cuboidal lens epithelial cells surrounded by PAS-positive material (arrow). H, PAX8-stained preparation corresponding to (F) highlighting the positive staining results in the nuclei of iris sphincter muscle (arrow). The lens epithelial cells seen in (G) also show positive staining results with PAX8 (inset). The fibrous component of the capsular fibrosis does not show positive staining results with PAX8. Stains, PAS (A, F, G), hematoxylin–eosin (B), CK5/6 (C), PAX8 (D, H), and vimentin (E); original magnifications, ×100 (A, C, E, F), ×200 (B, D, E, F), ×400 (G, H), and ×600 (all insets).