Graphs showing mean change in best-corrected visual acuity (BCVA) from baseline. A, Overall mean (95 % confidence interval [CI]) changes from baseline in BCVA Early Treatment Diabetic Retinopathy Study (ETDRS) letters over time, accounting for rescue treatment,∗ for all treated patients and by dose level. B, Percentage (95 % CI) of patients with a 2-line or more or 3-line or more gain in BCVA from baseline, accounting for rescue treatment,∗ for all treated patients (n = 12). ∗Last value before or on the day of rescue treatment carried forward. D = day; M = month.