Figure 2.

Graphs demonstrating transient pupillary light reflex (TPLR) results show objective light sensitivity improvements recorded with sepofarsen treatment in a cohort of 5 participants with light perception vision. Both (A) amplitude and (B) latency of the TPLR evoked with a white 40 cd/m² stimulus in dark-adapted eyes are evaluated. In patient P6, a white 4-cd/m² stimulus was used (Supplemental Fig 1). Upper panels show results at baseline and lower panels show the change from mean baseline at 3 months in control and study eyes. Boxplots show the extreme of the lower and upper whisker, lower and upper hinge, and median. Test–retest variability limits estimated from all baseline data are shown (dashed lines) in lower panels.