Figure 3.

Images showing the retinal structure of subject P10 at baseline (BL) and months 1 through 3 (M1, M2, and M3, respectively) in the untreated control eye and study eye, which received an intravitreal injection of 320 μg sepofarsen. En face images (square panels on left) display near-infrared autofluorescence representing retinal pigment epithelium melanization. The brighter central ellipse is the stereotypically retained region in CEP290-Leber congenital amaurosis, surrounded by loss of signal resulting from retinal degeneration and demelanization of the retinal pigment epithelium. The near-infrared autofluorescence images from months 1 through 3 have been registered to the BL image of each eye to allow comparison. Cross-sectional images (rectangular panels on right) are OCT scans along the horizontal meridian crossing the fovea. Calibration shown on lower right.