Figure 5.

Graphs showing specialized transient pupillary light reflex (TPLR) results of participant P10 at baseline and months 1 through 3 (M1, M2, and M3, respectively) in the untreated control eye and study eye, which received an intravitreal injection of 320 μg sepofarsen. A, Traces of mean pupillary diameter as a function of time for brief (1-second) red full-field flashes of 50 cd/m² luminance at baseline (thick gray lines, duplicated at each panel) and at M1, M2, and M3 after injection. Thick black traces are uninjected control eyes and green traces are injected study eyes. Evaluable TPLRs were missing at M1 for the control eye. A representative normal response (dashed line) shown for comparison. Stimulus marker and scale bar are shown. B, C, Constriction amplitude and latency changes from mean baseline for control (black symbols) and study (green symbols) eyes. Gray dashed line represents no change from baseline.