Table 2.
Comaparison of lipoprotein profiles
| Lipoproteins | Unit | Mean±Standard Deviation |
P Value |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Early Age-Related Macular Degeneration | Neovascular Age-Related Macular Degeneration |
Overall | Control | Control | Control | Early Age-Related Macular Degeneration | Earlyl Age-Related Macular Degeneration | Typical Neovascular Age-Related Macular Degeneration | |||
| Typical Neovascular Age-Related Macular Degeneration | Polypoidal Choroidal Vasculopathy | |||||||||||
| Conventional clinical lipid assay | ||||||||||||
| HDL cholesterol | mmol/l | 1.27 ± 0.34 | 1.33 ± 0.45 | 1.46 ± 0.33 | 0.0002 | 0.6918 | 0.0045 | 0.0007 | 0.1305 | 0.0731 | 0.9998 | |
| 1.46 ± 0.32 | 1.45 ± 0.34 | |||||||||||
| LDL cholesterol | mmol/l | 3.17 ± 0.87 | 3.08 ± 0.85 | 3.53 ± 1.03 | 0.0008 | 0.9234 | 0.0377 | 0.0388 | 0.0122 | 0.01 | 0.9792 | |
| 3.57 ± 1.03 | 3.51 ± 1.03 | |||||||||||
| NMR spectroscopy | ||||||||||||
| Total particle(s) concentration | ||||||||||||
| ApoA1 | mg/dl | 1.43 ± 0.16 | 1.47 ± 0.18 | — | 1.55 ± 0.27 | 0.0002 | 0.49 | — | 0.0001 | — | 0.0537 | — |
| HDL | 10–6 μmol/l | 8.13 ± 1.09 | 8.37 ± 1.06 | — | 9.07 ± 1.41 | < 0.0001 | 0.044 | — | < 0.0001 | — | 0.0727 | — |
| LDL | 10–7 nmol/l | 4.38 ± 1.25 | 4.35 ± 1.20 | — | 4.44 ± 1.65 | 0.9671 | - | — | - | — | - | — |
| VLDL and chylomicron | 10–8 nmol/l | 6.64 ± 2.98 | 5.76 ± 2.23 | — | 5.37 ± 2.25 | 0.0075 | 0.0816 | 0.0081 | — | 0.9512 | — | |
| Mean particle diameter, nm | ||||||||||||
| HDL | 9.84 ± 0.24 | 9.96 ± 0.27 | — | 9.97 ± 0.23 | 0.0001 | 0.0058 | — | 0.0002 | — | 0.9631 | — | |
| LDL | 23.54 ± 0.11 | 23.54 ± 0.10 | — | 23.59 ± 0.13 | 0.0002 | 0.8796 | — | 0.0003 | — | 0.0147 | — | |
| VLDL | 37.85 ± 1.56 | 37.35 ± 1.54 | — | 37.05 ± 1.33 | 0.0002 | 0.0821 | — | < 0.0001 | — | 0.3607 | — | |
| Lipoprotein subclass analysis | ||||||||||||
| HDL | ||||||||||||
| Very large | 10–7 μmol/l | 3.39 ± 1.69 | 4.51 ± 2.17 | — | 4.33 ± 1.92 | < 0.0001 | 0.0008 | — | 0.0005 | — | 0.8166 | — |
| Large | 10–7 μmol/l | 9.37 ± 4.33 | 11.63 ± 4.95 | — | 12.78 ± 4.96 | < 0.0001 | 0.0084 | — | < 0.0001 | — | 0.2587 | — |
| Medium | 10–7 μmol/l | 19.48 ± 3.45 | 19.48 ± 3.27 | — | 22.25 ± 4.54 | < 0.0001 | 1 | — | < 0.0001 | — | < 0.0001 | — |
| Small | 10–7 μmol/l | 49.28 ± 4.97 | 47.95 ± 4.82 | — | 51.47 ± 6.82 | 0.0002 | 0.3203 | — | 0.0109 | — | 0.0003 | — |
| IDL | 10–8 nmol/l | 9.58 ± 2.44 | 9.51 ± 2.43 | — | 9.92 ± 3.18 | 0.5258 | — | — | — | — | — | — |
| LDL | ||||||||||||
| Large | 10–8 nmol/l | 15.86 ± 4.48 | 15.79 ± 4.28 | — | 16.27 ± 5.80 | 0.7573 | — | — | — | — | — | — |
| Medium | 10–8 nmol/l | 12.87 ± 3.83 | 12.75 ± 3.67 | — | 12.98 ± 5.07 | 0.9422 | — | — | — | — | — | — |
HDL = high-density lipoprotein; IDL = intermediate density lipoprotein.; LDL = low-density lipoprotein; NMR = nuclear magnetic resonance; VLDL = very low-density lipoprotein; — = not available.
Data derived using an analysis of variance followed by the Tukey test. P < 0.05 was considered significant. Boldface indicates statistical significance.