Table 1.

Univariate and multivariate COX analysis of OS in NKTL patients.

Variables	Hazard Ratio	Std. Err.	p	[95% Conf. Interval]
Gender (male vs. female)	0.752	0.231	0.219	0.478	1.184
Age (<60 vs. ≥60)	1.333	0.262	0.274	0.797	2.229
clinical stage (I–II vs. III–IV)	5.575	0.223	<0.001 *	3.599	8.637
ECOG score (<2 vs. ≥2)	3.960	0.211	<0.001 *	2.618	5.991
circKIF4 (high expression vs. low expression)	0.606	0.208	0.016 *	0.403	0.912
LDH (<60U/L vs ≥60U/L)	2.962	0.210	<0.001 *	1.964	4.466
B symptoms (positive vs. negative)	1.379	0.210	0.122	0.918	2.073
regional lymph nodes invasion (negative vs. positive)	1.962	0.245	0.001 *	1.299	2.964
Multivariate analysis
clinical stage (I–II vs. III–IV)	1.747	0.290	0.055	0.989	3.084
ECOG score (<2 vs. ≥2)	1.166	0.296	0.603	0.654	2.081
circKIF4 (high expression vs. low expression)	0.500	0.223	0.002 *	0.323	0.774
LDH (<60U/L vs ≥60U/L)	0.741	0.232	0.196	0.471	1.167
regional lymph nodes invasion (negative vs. positive)	0.000	52.764	0.803	0.001	1.577

Abbreviations: OS: overall survival; ECOG: eastern cooperative oncology group; LDH: lactate dehydrogenase.* indicates p < 0.05.