Table 1.

Mutations in MPXV over various periods.

Gene	Residue	1965	2001	2018	2022	Epitopea
F8L MPXV DNA Polymerase	108	L	L	L	F	ISPDGCYSL (epitope 1)
	411	W	W	L	L	LTFDYVVTF
	428	I	T	I	I	(epitope 2)
	484	A	S	A	A
	501	I	V	I	I
	785	N	D	N	N
A22R Processivity factor	313	I	S	I	I	–
E5R Helicase (NTPase)	454	D	N	D	D	–
E4R Uracil Glycosylase	–	–	–	–	–	–
G9R PCNA ortholog	30	S	S	S	L	-
	88	D	D	D	N	-

^aBased on Song et al., 2013.