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. 2022 Oct 1;32(3):030501. doi: 10.11613/BM.2022.030501

Table 1. The summary of biomarkers relevance in various etiologies.

Biomarker Etiology Relevance Reference
HA HBV, HCV, AC, NAFLD Liver fibrosis stage evaluation by increased HA concentration (12, 13, 20, 21, 27, 32, 33)
HA HBV, HCV, NAFLD Healthy patients screening; differentiation from patients with liver fibrosis (14, 16, 24, 28, 30)
HA HBV Monitoring of antiviral treatment (17, 18)
LN HCV, HBV Liver fibrosis stage evaluation by increased LN concentration (12, 40-43)
LN HBV Monitoring of antiviral treatment (46)
PIIIP N-P HBV, AC Healthy patients screening; differentiation from patients with liver fibrosis (49-51)
PIIIP N-P Screening for MTX induced hepatic fibrosis (53, 54)
CIV HCV, HBV Liver fibrosis stage evaluation by increased CIV concentration (41, 59)
CIV HBV, NASH Healthy patients screening; differentiation from patients with liver fibrosis (50)
CG NA Healthy patients screening; differentiation from patients with liver fibrosis (62)
HA - hyaluronic acid. LN - laminin. PIIIP N-P - collagen type III N-peptide. CIV - type IV Collagen. CG - cholylglycine. HBV - hepatitis B virus, HCV - hepatitis C virus. AC - alcoholic cirrhosis. NAFLD - non-alcoholic fatty liver disease. MTX - methotrexate. NASH - non-alcoholic steatohepatitis. NA – not available.