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. 2022 Oct 6;14(19):4895. doi: 10.3390/cancers14194895

Figure 1.

Figure 1

HPV16 E7 variants examined in this study. Schematic representation of amino acid (AA) sequences of HPV16 E7 single AA substitution mutants and their location in functional domains. Variants from cancer-free controls shown above and variants from pre-cancer samples below the functional domain. The numbers 1 to number 98 indicate the amino acid position of E7 variants. *: cervical intraepithelial neoplasia 2 (CIN2); the CXXC motif is shown in red (AA.58–61 and 91–94). Conserved regions 1, 2 and 3 are indicated (CR1, CR2, CR3).