Table 3.
Univariate and multivariate Cox proportional hazards regression model analysis of OS before and after PSM.
| Variable | Before PSM | After PSM | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | 0.93 (0.68-1.26) | 0.634 | 0.68 (0.44-1.05) | 0.081 | ||||
| Sex | 0.78 (0.51-1.2) | 0.257 | 0.66 (0.33-1.31) | 0.235 | ||||
| Child-Pugh classification | 0.88 (0.52-1.49) | 0.633 | 0.73 (0.27-1.99) | 0.538 | ||||
| Metastasis | 1.15 (0.86-1.53) | 0.347 | 1.49 (1.01-2.19) | 0.043 | 1.62 (1.05 - 2.49) | 0.028 | ||
| PVTT Type I+II | 1.22 (0.9-1.66) | 0.209 | 1.13 (0.82 - 1.55) | 0.448 | 1.3 (0.85-1.99) | 0.233 | 0.79 (0.5 - 1.27) | 0.337 |
| PVTT Type III | 3.63 (2.32-5.68) | <0.001 | 2.97 (1.87 - 4.7) | 0.002 | 3.23 (1.79-5.82) | <0.001 | 2.1 (1.11 - 3.97) | 0.023 |
| AFP | 1.87 (1.39-2.5) | <0.001 | 1.60 (1.18 - 2.16) | 0.025 | 1.83 (1.24-2.7) | 0.002 | 1.32 (0.85 - 2.04) | 0.211 |
| HBV | 1.18 (0.87-1.59) | 0.282 | 1.25 (0.84-1.87) | 0.275 | ||||
| ECOG score | 0.76 (0.52-1.12) | 0.162 | 0.64 (0.4-1.02) | 0.06 | ||||
| TBIL | 1.02 (1.01-1.03) | 0.005 | 1.01 (1 - 1.03) | 0.106 | 1.03 (1.01-1.06) | 0.002 | 1.03 (1.01 - 1.06) | 0.005 |
| ALB | 0.99 (0.97-1.01) | 0.468 | 1 (0.97-1.02) | 0.766 | ||||
| ALT | 1 (1-1) | 0.609 | 1 (1-1.01) | 0.383 | ||||
| Cr | 0.99 (0.98-1) | 0.090 | 0.99 (0.97-1) | 0.129 | ||||
| Maximum tumor diameter | 1 (1-1.01) | 0.188 | 1 (1-1.01) | 0.610 | ||||
| Number of liver tumors=2 | 2.75 (1.81-4.18) | <0.001 | 2.42 (1.56 - 3.76) | <0.001 | 2.64 (1.47-4.74) | 0.001 | 2.58 (1.36 - 4.92) | 0.004 |
| Number of liver tumors≥3 | 3.21 (2.06-5.01) | <0.001 | 2.81 (1.77 - 4.45) | <0.001 | 3.58 (1.94-6.59) | <0.001 | 3.58 (1.83 - 7.00) | <0.001 |
| TACE | 0.93 (0.84-1.03) | 0.182 | 0.88 (0.76-1.02) | 0.082 | ||||
| Treatment | 0.45 (0.33-0.63) | <0.001 | 0.43 (0.31 - 0.61) | <0.001 | 0.43 (0.29-0.65) | <0.001 | 0.33 (0.21 - 0.53) | <0.001 |
Treatment: TACE-A and TACE-AP. All variables were included in a multivariate stepwise Cox regression analysis; only the variables with P < 0.05 in the final model are presented; HR, hazard ratio; CI, confidence interval.