Table 1.

Two-component systems in S. aureus and S. capitis.

Two-component system	S. aureus reference	S. capitis reference	Presence in S. capitis ssp. capitis (%)	Presence in S. capitis ssp. ureolyticus (%)	Function
walRK	MW0018	AYP1020_RS09955	100	100	Cell wall maintenance, cell viability
	MW0019	AYP1020_RS09960	100	100
hptSR	MW0198		0	0	Intracellular survival, uptake of hexose phosphate
	MW0199		0	0
lytSR	MW0236		0	0	Autolysis, eDNA release, biofilm
	MW0237		0	0
graRS	MW0621	AYP1020_RS00130	100	100	AMPs resistance, growth at low pH
	MW0622	AYP1020_RS00135	100	100
saeSR	MW0667	AYP1020_RS00365	100	100	Virulence factors regulation
	MW0668	AYP1020_RS00360	100	100
tcs7SR	MW1208	AYP1020_RS03075	100	100	Uncharacterised function
	MW1209	AYP1020_RS03080	100	100
arlRS	MW1304	AYP1020_RS03545	100	100	Pathogenesis mechanisms
	MW1305	AYP1020_RS03540	100	100
srrBA	MW1445	AYP1020_RS03875	100	100	Anaerobic respiration, metabolism, growth at low temperatures
	MW1446	AYP1020_RS03880	100	100
phoRP	MW1636	AYP1020_RS04760	100	100	Phosphate uptake and homeostasis
	MW1637	AYP1020_RS04765	100	100
airRS	MW1789	AYP1020_RS05370	100	100	Oxidative stress response
	MW1790	AYP1020_RS05375	100	100
varRS	MW1824	AYP1020_RS05700	100	100	Cell wall-affecting antibiotic resistance, cell wall biosynthesis
	MW1825	AYP1020_RS05705	100	100
agrCA	MW1962	AYP1020_RS06010	100	100	Quorom sensing control of adhesion and virulence factors
	MW1963	AYP1020_RS06005	100	100
kpdDE	MW2002	AYP1020_RS09655	100	100	Potassium homeostasis regulation
	MW2003	AYP1020_RS09660	100	100
hssRS	MW2282	AYP1020_RS07580	100	100	Heme metabolism regulation
	MW2283	AYP1020_RS07585	100	100
nreCB	MW2313	AYP1020_RS07750	100	100	Response to low oxygen, nitrate reduction
	MW2314	AYP1020_RS07755	100	100
braSR	MW2544	AYP1020_RS08920	100	100	Antimicrobial peptide resistance
	MW2545	AYP1020_RS08925	100	100

Presence and absence of the 16 TCS of S. aureus (MW2) described in S. capitis reference genome AYP1020 and isolates included in this study.