Table 1.
The outcomes and number of patients with affective disorders and healthy control along with the side of standardized mean difference (SMD) and the 95% confidence intervals with respect to zero SMD.
| Outcome Profiles | n Studies | Side of 95% Confidence Intervals | Patient Cases |
Control Cases |
Total Number of Participants | |||
|---|---|---|---|---|---|---|---|---|
| <0 | Overlap 0 and SMD < 0 |
Overlap 0 and SMD > 0 | >0 | |||||
| TRP | 29 | 13 | 12 | 2 | 2 | 1987 | 1918 | 3905 |
| TRP/CAAs | 7 | 2 | 5 | 0 | 0 | 113 | 219 | 332 |
| CAAs | 5 | 2 | 2 | 1 | 0 | 86 | 163 | 222 |
| KYN/TRP | 17 | 1 | 5 | 7 | 4 | 1727 | 1538 | 3265 |
| KYN | 17 | 4 | 8 | 2 | 3 | 1727 | 1538 | 3265 |
| KA/KYN | 14 | 2 | 9 | 3 | 0 | 1619 | 1378 | 2997 |
| (KYN + 3HK + 3HA + XA + QA + PA) | 26 | 6 | 10 | 4 | 6 | 1874 | 1752 | 3626 |
| KA | 13 | 5 | 4 | 3 | 1 | 1563 | 1338 | 2901 |
| AA | 3 | 1 | 2 | 0 | 0 | 170 | 149 | 319 |
| QA | 14 | 2 | 2 | 6 | 4 | 1461 | 1131 | 2592 |
TRP: tryptophan. KYN: kynurenine. KA: kynurenic acid. 3HK: 3-Hydroxykynurenine. 3HA: 3-Hydroxyanthranilic acid. XA: xanthurenic acid. QA: quinolinic acid. PA: picolinic acid. AA: anthranilic acid. CAAs: competing amino acids (valine + phenylalanine + tyrosine + leucine + isoleucine).